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KMID : 0877220060100020146
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Journal of Korean Epilepsy Society
2006 Volume.10 No. 2 p.146 ~ p.152
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Cognitive Profiles of Lamotrigine in Epilepsy Patients : A Comparative Study with Valproate
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Kang Kyung-Hun
Lee Jong-Mok
Lee Ho-Won
Jung Doo-Kyo
Suh Chung-Kyu
Kwon Soon-Hak
Park Sung-Pa
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Abstract
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Purpose: To identify cognitive effects of lamotrigine (LTG) compared with valproate (VPA) in epilepsy patients after 1 year of treatment.
Methods: Cognitive tests and subjective complaints of 22 patients with LTG monotherapy (50-200 mg/day) were retrospectively compared with those of 22 patients with VPA monotherapy (500-1300 mg/day) at 1 year of medication.
Results: LTG group did not show any significant difference in the performance of cognitive tests compared with VPA group. The incidence of cognitive complaints between two drugs were also not different. Both groups showed a better performance of list learning and Trail Making Test type A after antiepileptic drug medication.
Conclusion: The impact of LTG and VPA monotherapy on cognitive functioning is similar. Both drugs may not be harmful or rather slightly beneficial for cognitive functions.
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KEYWORD
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Adverse effects, Cognition, Lamotrigine, Valproate
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